Search Results
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Progress Update: Flex fund for clinical study participant reimbursement
Mar 16, 2021, 2:35 PM
Dr. Kyba provides an update on his clinical study reimbursement expenses.
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Progress Update: Travel Reimbursement for Clinical Study Participants
Feb 3, 2020, 1:34 PM
Dr. Kyba provides a brief update on our help with recruiting study participants.
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Progress Update: Exploring mechanisms of myopathology in FSHD
Feb 15, 2019, 11:32 AM
Dr. Kyba's final update on investigating what exactly is happening to muscles as FSHD progresses.
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U of M Researchers Allow FSHD Patients to See What DUX4 Protein Looks Like
Dec 17, 2018, 10:18 AM
Article by the University of Minnesota discussing the results of a projects funded in part by Friends of FSH Research.
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Progress Update: Mechanisms of Myopathology
Nov 16, 2018, 9:43 AM
Progress update from Dr. Kyba.
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Muscle Stem Cells from Teratomas
Jul 10, 2018, 7:42 PM
Michael Kyba's lab shows that functional skeletal muscle stem cells can be produced from mouse pluripotent stem cells without genetic modification through teratoma formation. As few as 40,000 teratoma-derived cells can regenerate 80% of total muscle volume, improve force generation, and mature into functional muscle stem cells in vivo.
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Research Funding: Drs. Aihara and Kyba want to know their enemy
Jan 11, 2015, 1:12 PM
Drs. Aihara and Kyba lay out a plan towards solving the crystal structure of DUX4.
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Walking through Dr. Michael Kyba’s latest mouse model of FSHD
Sep 2, 2014, 8:40 AM
An in-depth analysis of the latest publication on a mouse model for FSHD. What does it mean? Why do we need a mouse model?
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Friends of FSH Research and FSHD Canada Fund Two New Projects
Jul 16, 2014, 9:42 PM
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High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity
Jan 7, 2014, 9:45 AM
We have developed a high-throughput screen based on the toxicity of DUX4 when overexpressed in C2C12 myoblasts, and identified inhibitors of DUX4-induced toxicity from within a diverse set of 44,000 small, drug-like molecules.
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Corrected stem cells create functional muscle
Mar 6, 2013, 4:21 PM
An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells.
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Michael Kyba Receives MDA Grant
Feb 6, 2013, 2:38 PM
Michael Kyba Receives MDA Grant to Study Muscle Developmental Deficits in FSHD.
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Development of anti-DUX4 therapeutics for FSHD
Sep 6, 2012, 12:41 PM
The chemicals Dr Kyba’s group has identified may help us to understand the chemical pathways that can indirectly inhibit the muscle toxicity associated with the DUX4 gene.
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Development of anti-DUX4 therapeutics for FSHD
Oct 31, 2011, 5:50 PM
Test selected compounds for their efficacy in preventing damage caused by DUX4 expression.
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FSHD Muscle Nuclei Poised for DUX4 Expression
Oct 29, 2010, 4:14 PM
An international research consortium shows that FSHD muscle nuclei are poised for expression of the toxic DUX4 protein.
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September 2010 FSH Research Meeting
Sep 16, 2010, 3:08 PM
This brought together the various labs which have been collaborating in an effort to push ahead on FSH research through an open exchange of unpublished research.
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Biphasic Myopathic Phenotype of Mouse DUX, an ORF within Conserved FSHD-Related Repeats
Sep 9, 2009, 2:05 PM
Dr. Kyba's paper on linking high expression of mDUX to myoblast death.
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Dr. Michael Kyba: Evaluating the stem cell hypothesis for FSHD
Aug 1, 2008, 12:34 PM
Dr. Kyba will insert D4Z4 repeats into the mouse genome in ES at a site on the X-chromosome, known to enable tissue-specific expression of transgenes, and to tolerate dominant lethal genes. He will study whether the presence of these repeats affects differentiation of the ES cells, and will produce mice bearing D4Z4 repeats, as a potential animal model for FSHD.