Mar 16, 2021, 2:35 PM
Dr. Kyba provides an update on his clinical study reimbursement expenses.
Feb 3, 2020, 1:34 PM
Dr. Kyba provides a brief update on our help with recruiting study participants.
Feb 15, 2019, 11:32 AM
Dr. Kyba's final update on investigating what exactly is happening to muscles as FSHD progresses.
Dec 17, 2018, 10:18 AM
Article by the University of Minnesota discussing the results of a projects funded in part by Friends of FSH Research.
Nov 16, 2018, 9:43 AM
Progress update from Dr. Kyba.
Jul 10, 2018, 7:42 PM
Michael Kyba's lab shows that functional skeletal muscle stem cells can be produced from mouse pluripotent stem cells without genetic modification through teratoma formation. As few as 40,000 teratoma-derived cells can regenerate 80% of total muscle volume, improve force generation, and mature into functional muscle stem cells in vivo.
Jan 11, 2015, 1:12 PM
Drs. Aihara and Kyba lay out a plan towards solving the crystal structure of DUX4.
Sep 2, 2014, 8:40 AM
An in-depth analysis of the latest publication on a mouse model for FSHD. What does it mean? Why do we need a mouse model?
Jul 16, 2014, 9:42 PM
Jan 7, 2014, 9:45 AM
We have developed a high-throughput screen based on the toxicity of DUX4 when overexpressed in C2C12 myoblasts, and identified inhibitors of DUX4-induced toxicity from within a diverse set of 44,000 small, drug-like molecules.
Mar 6, 2013, 4:21 PM
An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells.
Feb 6, 2013, 2:38 PM
Michael Kyba Receives MDA Grant to Study Muscle Developmental Deficits in FSHD.
Sep 6, 2012, 12:41 PM
The chemicals Dr Kyba’s group has identified may help us to understand the chemical pathways that can indirectly inhibit the muscle toxicity associated with the DUX4 gene.
Oct 31, 2011, 5:50 PM
Test selected compounds for their efficacy in preventing damage caused by DUX4 expression.
Oct 29, 2010, 4:14 PM
An international research consortium shows that FSHD muscle nuclei are poised for expression of the toxic DUX4 protein.
Sep 16, 2010, 3:08 PM
This brought together the various labs which have been collaborating in an effort to push ahead on FSH research through an open exchange of unpublished research.
Sep 9, 2009, 2:05 PM
Dr. Kyba's paper on linking high expression of mDUX to myoblast death.
Aug 1, 2008, 12:34 PM
Dr. Kyba will insert D4Z4 repeats into the mouse genome in ES at a site on the X-chromosome, known to enable tissue-specific expression of transgenes, and to tolerate dominant lethal genes. He will study whether the presence of these repeats affects differentiation of the ES cells, and will produce mice bearing D4Z4 repeats, as a potential animal model for FSHD.
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