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Progress Update: Targeting Epigenetic Silencing of the 4qD4Z4 repeat array in FSHD
Jan 31, 2014
Jong-Won Lim progress update.
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10th Anniversary FSH Auction
Jan 30, 2014
An amazing turnout and show of support.
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Regeneration of Human Muscle in Mice
Jan 18, 2014
Dr. Kathryn Wagner provides a much needed tool.
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Science journal promotes transparency of data
Jan 17, 2014
Science joins Nature Publishing Group to Improve Reproducibility.
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Parallels Between SMCHD1 and X Chromosome
Jan 16, 2014
Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway.
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GlaxoSmithKline joins Tapscott team at the Hutch
Jan 13, 2014
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Progress Update: Postnatal modeling of FSHD in mice
Jan 8, 2014
The research goals of 2011-13 were to 1) create a model of FSHD that displayed features of the disease in muscles of laboratory mice through production of human DUX4 protein and 2) to test a therapeutic approach to block production of DUX4 protein in patient cell lines grown in tissue culture dishes in the laboratory.
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High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity
Jan 7, 2014
We have developed a high-throughput screen based on the toxicity of DUX4 when overexpressed in C2C12 myoblasts, and identified inhibitors of DUX4-induced toxicity from within a diverse set of 44,000 small, drug-like molecules.