Investigators: Ellen M Paatela, Stephen Tapscott MD PhD
Category: Research - Basic
Mentor: Stephen J Tapscott
Total proposal: $83,993
DUX4, the causative gene of FSHD, is normally silenced in muscle cells by a complex mix of genetic and epigenetic factors. However, many of these factors and the mechanisms by which they initiate and maintain silencing of DUX4 are still unknown. My project focuses on the development of a functional silencing assay that can be used to identify the pathways and factors that silence DUX4 expression. My silencing assay will also provide a simple and robust tool for screening potential FSHD therapeutics.
Grant Information
Date awarded: Jul 1, 2024
End date: Jun 30, 2025
Amount awarded: $14,087
Wellstone Center for Muscular Dystrophy Training Core
Grant Co-Funding:
The Chris Carrino Foundation for FSHD
Ellen M Paatela
Graduate Research Assistant
Fred Hutchinson Cancer Center
Stephen Tapscott MD PhD
Full Member
Fred Hutchinson Cancer Research Center
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