Full Member
Fred Hutchinson Cancer Research Center
The Tapscott lab focuses on gene transcription in a chromatin context in normal development and disease. The lab uses the myogenic transcription factor MyoD to study how complex programs of gene expression unfold during cell differentiation. In addition, the lab studies gene expression in rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other areas of research in the lab include the formation of palindromes in the human cancer genome, gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.
Grants Awarded
Jul 1, 2024
Research - Basic
Research - Basic
Create a physiologically relevant FSHD tissue model that can be used in preclinical therapeutic drug testing.
Jul 1, 2024
Research - Basic
Research - Basic
Development of a functional silencing assay that can be used to identify the pathways and factors that silence DUX4 expression.
May 1, 2023
Research - Basic
Research - Basic
This proposal seeks to determine whether pigs will be a better model and will analyze gene expression and histology in two different models of FSHD based on the expression of DUX4 in pig muscle cells, and whether cells of the immune system, T cells and B cells, are responding to FSHD muscle and circulating in the blood to other muscles of the body and possibly cause inflammation.
Nov 1, 2022
Research - Basic
Research - Basic
Determine the composition of HSATII-derived ribonucleoprotein complexes and the consequence of their formation on cell function and elucidate the molecular mechanisms regulating HSATII regions.
Jun 1, 2020
Research - Basic
Research - Basic
In coordination with the Wellstone Muscular Dystrophy Cooperative Research Center for research in Seattle, Friends is providing co-funding for a one-year fellowship.
Jun 1, 2019
Research - Basic
Research - Basic
In coordination with the Wellstone Muscular Dystrophy Cooperative Research Center for research in Seattle, Friends is providing co-funding for a one-year fellowship.
May 7, 2018
Research - Basic
Research - Basic
Support for professional dedicated lab personnel.
Nov 25, 2011
Research - Basic
Research - Basic
Develop cells that can be easily monitored for DUX4 activity and show that these cells can be used to identify drugs that would be candidate treatments for FSHD. This will be an important step toward attracting the interest of pharmaceutical companies and developing a treatment for FSHD that can be advanced into clinical trials.
May 12, 2016
Research - Clinical
Research - Clinical
Purchase of a QMA system to allow the University of Washington Wellstone Center to participate in the proposed FSHD Clinical Trials Network.
Sep 15, 2009
Research - Basic
Research - Basic
Drs. Tapscott and Miller aim to use this grant to finalize the preliminary studies and applications to NIH for funding an international cooperative study on FSHD.
Aug 15, 2008
Research - Basic
Research - Basic
Dr. Stephen Tapscott and colleagues set out to determine whether DUX4 and/or transcription from D4Z4 are likely candidates for FSH Muscular Dystrophy.
Jun 14, 2006
Research - Basic
Research - Basic
Search for products of transcription originating from the D4Z4 repeat and surrounding regions in differentiating cells.
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