friends of FSH Research


Effects of FRG1 on muscle behavior

Investigators: Brian K Kennedy PhD and Stephen D Hauschka PhD

Recent transgenic studies suggest that FRG1 over-expression results in the mis-splicing of skeletal troponin and myotuburlarin related protein-1 and a muscular dystrophy phenotype (Gabellini et al. 2006). We are investigating FRG1 expression during myoblast growth and differentiation in vitro. We are also studying potential interactions between FRG1 and the D4Z4 repressor complex; and we are developing an in vitro splicing assay to analyze FRG1’s role in MTMR1 splicing.

Related Material

Publication: Decreased Proliferation Kinetics of Mouse Myoblasts Overexpressing FRG1

Grant Information

Date awarded: Oct 01, 2005
End date: Sep 30, 2008
Amount awarded: $150,000

Brian K Kennedy PhD
President and CEO
Buck Institute for Research on Aging

Stephen D Hauschka PhD
Professor of Biochemistry
University of Washington