Investigators: Hideki Aihara PhD, Michael Kyba PhD
Category: Research - Basic
The DUX4 protein causes FSHD and is therefore the primary target of drug development. In order to better understand this protein, and to understand how potential drugs may work to inhibit the protein, it will be essential to determine the protein’s structure at the atomic level. This research aims towards solving the DUX4 structure by identifying conditions under which crystals of the DUX4 protein can be grown. Such crystals can then be used to solve the three dimensional atomic structure of the DUX4 protein using X-ray crystallography.
Publication: Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA
Article: Researchers Allow Muscular Dystrophy Patients to See What the Protein that Damages Their Muscles Looks Like
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