Investigators: Hideki Aihara PhD, Michael Kyba PhD
Category: Research - Basic
The DUX4 protein causes FSHD and is therefore the primary target of drug development. In order to better understand this protein, and to understand how potential drugs may work to inhibit the protein, it will be essential to determine the protein’s structure at the atomic level. This research aims towards solving the DUX4 structure by identifying conditions under which crystals of the DUX4 protein can be grown. Such crystals can then be used to solve the three dimensional atomic structure of the DUX4 protein using X-ray crystallography.
Related Information
Publication: Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA
Grant Information
Date awarded: Jan 1, 2015
End date: Jun 30, 2015
Amount awarded: $33,397
University of Minnesota
Grant Co-Funding:
FSHD Canada Foundation
Hideki Aihara PhD
Associate Professor
University of Minnesota
Michael Kyba PhD
Professor of Pediatrics
University of Minnesota
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