Investigators: Hideki Aihara PhD, Michael Kyba PhD
Category: Research - Basic
The DUX4 protein is a key player for the development of FSHD and constitutes a primary target for drug therapy. In order to understand the function of DUX4 and devise molecular models for drugs that inhibit its function, it is essential to know the three-dimensional structure of DUX4 at the atomic level. In this research proposal, we will use a combined approach including X-ray crystallography and NMR spectroscopy to determine the structure of DUX4 DNA-binding domain free and bound to its target DNA. This synergistic approach will make it possible to determine the motions of the protein both free and in the bound state and identify sites for rational drug design.
Hideki Aihara, Tracy Dinh John Lee
Related Information
Publication: Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA
Grant Information
Date awarded: Mar 1, 2016
End date: Sep 13, 2017
Amount awarded: $65,401
University of Minnesota
Hideki Aihara PhD
Associate Professor
University of Minnesota
Michael Kyba PhD
Professor of Pediatrics
University of Minnesota
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