A Biomechanics-Based Bridge from Muscle MRI to Function in FSHD Trials

Investigator: Silvia Blemker PhD

Category: Research - Translational

Muscle MRI is becoming one of the most powerful tools for tracking disease progression in FSHD and measuring whether new therapies are working. However, doctors and researchers still face a major challenge: MRI changes do not always match changes in strength or daily function. Some patients show clear improvement on scans without meaningful functional benefit, while others experience important strength changes that seem disproportionate to MRI findings. This project will develop advanced computer models that connect MRI scans directly to muscle mechanics and strength. By simulating how fat replacement and muscle loss occur in different regions of a muscle, we can predict when MRI progression will truly translate into functional decline and when improvement is likely to produce meaningful benefit. The results will help clinical trials interpret MRI biomarkers more effectively, identify which muscles matter most for functional outcomes, and guide the development of better endpoints for future therapies. Ultimately, this work will strengthen the bridge between imaging, strength, and patient impact in FSHD.